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M. A. Dimopoulos, E. Kastritis, D. Christoulas, M. Migkou, M. Gavriatopoulou, M. Gkotzamanidou, M. Iakovaki, C. Matsouka, D. Mparmparoussi, M. Roussou, E. Efstathiou and E. Terpos, “Treatment of Patients with Relapsed/Refractory Multiple Myeloma with Lenalidomide And Dexamethasone with or without Bortezomib: Prospective Evaluation of the Impact of Cytogenetic Abnormalities and of Previous Therapies,” Leukemia: Official Journal of the Leukemia Society of America, Vol. 24, No. 10, 2010, pp. 1769-1778.

has been cited by the following article:

• TITLE: Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone

  AUTHORS: Masao Hagihara, Morihiro Inoue, Jian Hua, Nobuyasu Iwaki, Kosuke Yoshioka, Takeshi Kobayashi

  KEYWORDS: Plasmacytoma; Testis; Lenalidomide

  JOURNAL NAME: Open Journal of Pathology, Vol.2 No.4, October 31, 2012

  ABSTRACT: We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed with IgG-λ-type multiple myeloma and treated with melphalan and prednisolone plus bortezomib, achieving a complete remission. Four months later, his left scrotum began to swell and pathological investigation of a needle biopsy specimen revealed proliferation of plasma cells expressing IgG-λ, confirming myeloma recurrence. However, bone marrow aspiration samples showed no significant increase in myeloma cells and there was no skewed deviation of the K/λ ratio on flow-cytometric analysis. The extramedullary tumors disappeared completely soon after treatment with lenalidomide plus dexamethasone, and the patient was judged to be in very good partial remission based on negative M-protein results by serum immunoelectrophoresis. This is the first report, to our knowledge, describing complete disappearance of a testicular plasmacytoma after treatment with lenalidomide as the key-drug.