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M. Dimopoulos, A. Spencer, M. Attal, H. M. Prince, J. L. Harousseau, A. Dmoszynska, J. San Miguel, A. Hellmann, T. Facon, R. Foa, A. Corso, Z. Masliak, M. Olesnyckyj, Z. Yu, J. Patin, J. B. Zeldis and R. D. Knight, “Lenalidomide plus Dexamethasone for Relapsed or Refractory Multiple Myeloma,” The New England Journal of Medicine, Vol. 357, No. 21, 2007, pp. 2123-2132.

has been cited by the following article:

• TITLE: Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone

  AUTHORS: Masao Hagihara, Morihiro Inoue, Jian Hua, Nobuyasu Iwaki, Kosuke Yoshioka, Takeshi Kobayashi

  KEYWORDS: Plasmacytoma; Testis; Lenalidomide

  JOURNAL NAME: Open Journal of Pathology, Vol.2 No.4, October 31, 2012

  ABSTRACT: We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed with IgG-λ-type multiple myeloma and treated with melphalan and prednisolone plus bortezomib, achieving a complete remission. Four months later, his left scrotum began to swell and pathological investigation of a needle biopsy specimen revealed proliferation of plasma cells expressing IgG-λ, confirming myeloma recurrence. However, bone marrow aspiration samples showed no significant increase in myeloma cells and there was no skewed deviation of the K/λ ratio on flow-cytometric analysis. The extramedullary tumors disappeared completely soon after treatment with lenalidomide plus dexamethasone, and the patient was judged to be in very good partial remission based on negative M-protein results by serum immunoelectrophoresis. This is the first report, to our knowledge, describing complete disappearance of a testicular plasmacytoma after treatment with lenalidomide as the key-drug.