TITLE:
Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone
AUTHORS:
Masao Hagihara, Morihiro Inoue, Jian Hua, Nobuyasu Iwaki, Kosuke Yoshioka, Takeshi Kobayashi
KEYWORDS:
Plasmacytoma; Testis; Lenalidomide
JOURNAL NAME:
Open Journal of Pathology,
Vol.2 No.4,
October
31,
2012
ABSTRACT: We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed with IgG-λ-type multiple myeloma and treated with melphalan and prednisolone plus bortezomib, achieving a complete remission. Four months later, his left scrotum began to swell and pathological investigation of a needle biopsy specimen revealed proliferation of plasma cells expressing IgG-λ, confirming myeloma recurrence. However, bone marrow aspiration samples showed no significant increase in myeloma cells and there was no skewed deviation of the K/λ ratio on flow-cytometric analysis. The extramedullary tumors disappeared completely soon after treatment with lenalidomide plus dexamethasone, and the patient was judged to be in very good partial remission based on negative M-protein results by serum immunoelectrophoresis. This is the first report, to our knowledge, describing complete disappearance of a testicular plasmacytoma after treatment with lenalidomide as the key-drug.