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F. Mertens, C. D. Fletcher, C. R. Antonescu, J. M. Coindre, M. Colecchia, et al., “Clinicopathologic and Molecular Genetic Characterization of Low-Grade Fibromyxoid Sarcoma, and Cloning of a Novel FUS/CREB3L1 Fusion Gene,” Laboratory Investigation, Vol. 85, No. 3, 2005, pp. 408-415. doi:10.1038/labinvest.3700230

has been cited by the following article:

• TITLE: Molecular Particularity in Rare Tumour of Buttock: Case Report and Literature Review

  AUTHORS: El Fatemi Hinde, Florence Mishellany, Pierre Gimbergues, Frédérique Penault-Llorca

  KEYWORDS: Deep Soft Tissue; Fibromyxoid Sarcoma; Hyalinizing Spindle Cell Tumor; RT-PCR; Fusion Transcripts; CREB3L1

  JOURNAL NAME: Open Journal of Pathology, Vol.2 No.4, October 31, 2012

  ABSTRACT: Introduction: Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Case Report: Reported herein is a case of primary tumour of buttock HSCT that had rare FUS-CREB3L1 fusion transcripts, a product of characteristic chromosomal abnormality t (7; 16) (q33; p11) of HSCT and LGFMS. The patient was a 48-year-old man who had a large solitary mass in the buttock. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L1 fusion transcripts. In our knowledge is the second case may display a variant FUS/CREB3L1 fusion transcript in international literature. Conclusion: LGFMS and HSCT probably have a wider spectrum of morphologic features than previously thought, the awareness of which will help pathologists to avoid diagnostic pitfalls. Demonstration of the t (7; 16) translocation will help to diagnose difficult cases with unusual histologic features.