TITLE:
In Vitro Evaluation of Polyurethane-Chitosan Scaffolds for Tissue Engineering
AUTHORS:
Imelda Olivas-Armendariz, Perla García-Casillas, Adriana Martel Estrada, Alberto Martínez-Villafañe, Laura A. A. de la Rosa, Carlos A. Martínez-Pérez
KEYWORDS:
Biomaterials; Composite
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.3 No.4,
October
31,
2012
ABSTRACT: In this work the use of Polyurethane (PU)-Chitosan(CH) scaffolds prepared by thermal induced phase separation (TIPS) for osteoblast proliferation and bone mineralization is described. Primary rat calvaria osteoblasts were seeded in the scaffolds and it was shown that supported cell adhesion and growth. The behavior osteoblast cells growing in the scaffold in function of the different ratio of PU and CH is presented. The results showed that TIPS is an appropriate technique for the production of PU-CH scaffolds with high potential for application as cell scaffolds in bone tissue engineering.