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Crespi, F., Lazzarini, C., Andreoli, M. and Vecchiato, E. (2000) Voltammetric and functional evidence that N-methyl-D-aspartate and substance P mediate rat vascular relaxation via nitrogen monoxide release. Neuroscience Letters, 287(3), 219-222.

has been cited by the following article:

• TITLE: N-methyl-D-aspartate (NMDA) mediates vascular relaxation via nitric oxide (NO) in rats but not in mice

  AUTHORS: Francesco Crespi

  KEYWORDS: Nitric Oxide; Amperometry; Carbon Fibre Micro-Electrodes; Mice; Rats; Aortic Rings; N-Methyl- D-Aspartate; Substance P

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.1 No.4, October 27, 2010

  ABSTRACT: Amperometric studies have indicated that substance P as well as NMDA stimulates release of NO in rat aortic rings. These data have been confirmed by functional observations of vaso-relaxant action of NMDA within noradrenaline pre-contracted aortic rings, supporting the presence of NMDA receptor in rat aortic rings. It is known that the enzyme endothelial NO synthase (eNOS) mediates vasodilatation not only in rats, but also in C57BL6 mice aortic ring, indicating that in this blood vessel NO is the endogenous endothelium-derived vasodilator. In this work, amperometry together with specifically nitrites insensitive micro-biosensors have been applied to examine the effect of NMDA and substance P upon NO release in rat and in two strains of mice aortic rings. The electrochemical data monitored demonstrate that NMDA mediates vascular relaxation via NO in rats but not in mice. These results are supported by functional data, therefore they suggest that NMDA receptors are “not responding” within these experimental conditions in mice aortic rings.