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R. Lefloch, J. Pouyssegur and P. Lenormand, “Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels,” Molecular Cell Biology, Vol. 28, No. 1, 2008, pp. 511-527.

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• TITLE: The Role of Prolactin in the Evolution of Prostate Cancer

  AUTHORS: Maria Elena Hernandez, Michael J. Wilson

  KEYWORDS: Second Messengers; Prolactin Receptor; Androgens; Hyperprolactinemia

  JOURNAL NAME: Open Journal of Urology, Vol.2 No.3A, October 30, 2012

  ABSTRACT: Today there is significant information indicating an effect of prolactin on the prostate gland. It has been shown to be involved in mechanisms leading to the synthesis of some proteins such as PSA and cathepsin D, synthesis of citrate and accumulation of zinc. Also, at the behavioral level, prolactin is known to control some aspects of reproduction, including documentation on the physiology of the prostate and the possibility to trigger pathologies in this sex gland. Although the later still is not clear, there is a correlation between the level of prolactin and the presence of prostate pathologies. Thus, the aim of this review is to show how prolactin is involved in the progression of some pathologies of this male sexual gland.