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Roy, D., Rowe, B.H., Stiell, I.G., Coutu, B., Ip, J.H., Phaneuf, D., et al., CRAFT Investigators (2004) A rando- mized, controlled trial of RSD1235, a novel antiarrhythmic agent, in the treatment of recent onset atrial fibrillation. Journal of the American College of Cardiology, 44, 2355- 2361. doi:10.1016/j.jacc.2004.09.021

has been cited by the following article:

• TITLE: Novel therapies for treating atrial fibrillation

  AUTHORS: Raj Parikh, Philip J. Kadowitz

  KEYWORDS: Atrial Fibrillation; Atrial Flutter; Arrhythmia;Anticoagulation; Stroke

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.2 No.4, October 30, 2012

  ABSTRACT: Atrial fibrillation is the most common cardiac arrhythmia and is a major risk factor for stroke, heart failure, and death. Current treatments focus on anti-coagulation as well as rate-control and rhythm-control strategies. Frequent INR checks associated with warfarin along with several adverse side effects of anti-arrhythmics have propelled investigations into novel treatments for atrial fibrillation. Research is focused not only on pioneering new pharmacological antico- agulation and anti-arrhythmic agents but also on improving surgical techniques in hopes of treating the arrhythmia. Here, we first briefly discuss the current treatment options, both pharmacological and non-pharmacological, for atrial fibrillation. We then present a focused review of recent animal and human investigations that examine the use of novel an-ticoagulation agents, mechanisms of new anti-arrhythmics, analyze potential triggers of atrial fibrillation, and highlight the role of genetics in atrial fibrillation.