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POISE Study Group, Devereaux, P.J., Yang, H., Yusuf, S., Guyatt, G., Leslie, K., Villar, J.C., Xavier, D., Chrolavicius, S., Greenspan, L., Pogue, J., Pais, P., Liu, L., Xu, S., Malaga, G., Avezum, A., Chan, M., Montori, V.M., Jacka, M. and Choi, P. (2008) Effects of extended- release metoprolol succinate in patients undergoing non- cardiac surgery (POISE trial): A randomised controlled trial. Lancet, 371, 1839-1847.
doi:10.1016/S0140-6736(08)60601-7
has been cited by the following article:
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TITLE:
Prognostic implications of type 2 myocardial infarctions
AUTHORS:
Hazim El-Haddad, Elijah Robinson, Katrina Swett, Gretchen L. Wells
KEYWORDS:
Type 2 Myocardial Infarction; Postoperative Myocardial Infarction; Troponin; Sepsis
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.2 No.4,
October
30,
2012
ABSTRACT: Purpose: A type 2 myocardial infarction (MI) is due to ischemia from increased oxygen demand or decreased supply. It is not an infrequent complication following non-cardiac surgery or in the setting of acute medical illness. The purpose of this study was to determine whether type 2 MIs had a worse prognosis than a type 1 MI. Methods: The hospital database of a large terti-ary-level academic medical center was queried for all patients with a troponin I ≥ 1.6 ng/mL during a one-year period. The outcomes of patients with a type 2 MI were compared to those with a type 1 MI. Results: This retrospective study found that a type 2 MI is more lethal than the usual type 1 MI, particularly among women and the elderly. There was no statistical difference in outcomes between those that occurred in the post-operative setting compared to those that occurred in the setting of acute medical illness. Conclusions: Type 2 MIs are common and are associated with increased mortality, as compared with type 1 MIs. To date, no guidelines exist for the management of this type of MI. Further research into underlying mechanisms resulting in type 2 MI as well as potential treatment strategies is needed.