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C. W. Whitney, W. Sause, B. N. Bundy, et al., “A Randomized Comparison of Fluorouracil Plus Cisplatin versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix with Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study,” Journal of Clinical Oncology, Vol. 17, No. 5, 1999, pp. 1339-1348.

has been cited by the following article:

• TITLE: Prognostic Impact of Carcinoembryonic Angtigen (CEA) in Locally Advanced Cervical Cancer Treated with Concurrent Chemoradiotherapy

  AUTHORS: Kiyosumi Shibata, Hiroaki Kajiyama, Mik Mizuno, Eiko Yamamoto, Fumitaka Kikkawa

  KEYWORDS: Cervical Cancer; Chemoradiotherapy; Recurrence; Prognostic Factor; Carcinoembryonic Angtigen (CEA)

  JOURNAL NAME: Surgical Science, Vol.3 No.10, October 18, 2012

  ABSTRACT: Objective: To identify prognostic factors in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy (CCRT). Methods and Materials: We analyzed 76 patients with FIGO stage IB2 - IVb cervical cancer treated with CCRT between 2001 and 2006 at the Nagoya University Hospital. Patients with an advanced cervical cancer treated with CCRT. Overall survival (OS) and Progression-free survival (PFS) rates were estimated using the Kaplan-Meier method. The log-rank test was used to test differences in survival. Fisher's exact test was employed for univariate analysis. The Cox proportional hazard model was used for multivariate analysis. Results: The median age was 52, and the median follow-up period was 36 months. The 5 - year OS and PFS rates of all patients were 88.2% and 72.4%, respectively. Twenty-one of the 76 patients were diagnosed with recurrence. A higher serum CEA before CCRT was an independent predictive factor for a poor prognosis on multivariate analysis. Conclusions: A high level of serum CEA was a predictive factor for a poor prognosis. New strategies should be considered to control disease in this group of patients.