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Dumke, C.L., Mark, D.J., Angela, M.E., Nieman, D.C., Carmichael, M.D., Quindry, J.C., Travis, T.N., Utter, A..C, Gross, G.S.J., Henson, D.A., McAnulty, S.R. and McAnulty, L.S. (2009) Successive bouts of cycling stimulates genes associated with mitochondrial biogenesis. European Journal of Applied Physiology, 107, 419-427.
doi:10.1007/s00421-009-1143-1
has been cited by the following article:
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TITLE:
The modulation of sirtuins and apoptotic proteins in rats after exhaustive exercise
AUTHORS:
Gabriella Marfe, Vincenzo Manzi, Marco Tafani, Bruna Pucci, Alessandra Gambacurta, Matteo Antonio Russo, Paola Sinibaldi-Salimei
KEYWORDS:
Cardiac Muscle; Skeletal Muscle; Bax; Bcl-2; SIRT1; SIRT7
JOURNAL NAME:
Open Journal of Molecular and Integrative Physiology,
Vol.2 No.3,
August
23,
2012
ABSTRACT: A large body of evidence shows that a single bout of strenuous exercise induces oxidative stress in circu- lating human lymphocytes leading to lipid peroxide- tion, DNA damage, mitochondrial perturbations, and protein oxidation. In a training experiment, Wistar rats were divided into control group (CG) and exer- cise group (EG). After a running level exercise until exhaustion, we observed an increase in the mRNA content and protein expression of SIRT1 and SIRT7 in the EG compared to the CG. Moreover, such train- ing exercise did not change mRNA transcripts and protein expression of FOXO3A and GADD45. We also observed an increase of pro-apoptotic protein bax and a decrease of the anti-apoptotic protein bcl-2 in the EG. Accordingly, we observed a caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage only in EG rats. Statistical analysis of the data showed a significant correlation between SIRT1 and SIRT7 expression and apoptotic proteins such as bax, bcl-2 in both tissues. We conclude that, in both muscle, such exercise activates both a damaging apoptotic mecha- nism with bax increase and bcl-2 decrease and a counterbalancing protective mechanism with SIRT1 and SIRT7 increase.