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G. Choudhary and R. K. Peddinti, “An Expeditious, Highly Efficient, Catalyst-Free and Solvent-Free Synthe- sis of Nitroamines and Nitrosulfides by Michael Addi- tion,” Green Chemistry, Vol. 13, No. 2, 2011, pp. 2276- 2282. doi:10.1039/c0gc00830c

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• TITLE: Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions

  AUTHORS: Saeed Balalaie, Shahrzad Abdolmohammadi, Bita Soleimanifard

  KEYWORDS: Arylmethylidene Pyruvic Acid; Hexahydro-2-quinolinecarboxylic Acids; Solvent-Free Conditions; One-Pot Three-Component Reaction

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.3, September 28, 2012

  ABSTRACT: A simple and fastthree-component synthesis of new and biologically active hexahydro-2-quinolinecarboxylic acid scaf-fold 4 was carried out using cyclocondensation reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 under solvent-free conditions and at room temperature. This protocol has the advantages of facility, easy work-up, high yields, short reaction time and environmentally friendly character.