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N. Bergans, W. Stalmans, S. Goldmann and F. Vanstapel, “Molecular Mode of Inhibition of Glycogenolysis in Rat Liver by the dihydropyridine Derivative, BAY R3401: Inhibition and Inactivition of Glycogen Phosphorylase by an Activated Metabolite,” Diabetes, Vol. 49, No. 9, 2000, pp. 1419-1426. doi:10.2337/diabetes.49.9.1419

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• TITLE: Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions

  AUTHORS: Saeed Balalaie, Shahrzad Abdolmohammadi, Bita Soleimanifard

  KEYWORDS: Arylmethylidene Pyruvic Acid; Hexahydro-2-quinolinecarboxylic Acids; Solvent-Free Conditions; One-Pot Three-Component Reaction

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.3, September 28, 2012

  ABSTRACT: A simple and fastthree-component synthesis of new and biologically active hexahydro-2-quinolinecarboxylic acid scaf-fold 4 was carried out using cyclocondensation reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 under solvent-free conditions and at room temperature. This protocol has the advantages of facility, easy work-up, high yields, short reaction time and environmentally friendly character.