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S. Bogialli, G. D’Ascenzo, A. Di Corcia, A. Laganà and S. Nicolardi, “A Simple and Rapid Assay Based on Hot Water Extraction and liquid Chromatography-Tandem Mass Spectrometry for Monitoring Quinolone Residues in Bovine Milk,” Food Chemistry, Vol. 108, No. 1, 2008, pp. 2354-2360. doi:10.1016/j.foodchem.2007.10.044
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TITLE:
Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions
AUTHORS:
Saeed Balalaie, Shahrzad Abdolmohammadi, Bita Soleimanifard
KEYWORDS:
Arylmethylidene Pyruvic Acid; Hexahydro-2-quinolinecarboxylic Acids; Solvent-Free Conditions; One-Pot Three-Component Reaction
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.3,
September
28,
2012
ABSTRACT: A simple and fastthree-component synthesis of new and biologically active hexahydro-2-quinolinecarboxylic acid scaf-fold 4 was carried out using cyclocondensation reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 under solvent-free conditions and at room temperature. This protocol has the advantages of facility, easy work-up, high yields, short reaction time and environmentally friendly character.