TITLE:
Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against Salmonella gallinarum
AUTHORS:
Maduike C. O. Ezeibe, George N. Anosa, Okechi K. Okorie, Nnenna P. Elendu-Eleke, Obianuju N. Okoroafor, Augustine A. Ngene, Ogechukwu N. Chikelu
KEYWORDS:
Antibiotic Resistance; Synthetic Aluminium-Magnesium Silicate; Stabilization; Salmonella gallinarum
JOURNAL NAME:
Health,
Vol.4 No.9,
September
28,
2012
ABSTRACT: To test if stabilizing Ampicillin trihydrate (AT) with Aluminium-Magnesium Silicate (AMS) can enhance its antibacterial activities, different concentrations of AT solution and of a formulation of AT in the AMS, were made and used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg/Kg (AT), 10 mg/Kg (AT in AMS), 7.5 mg/Kg (AT), 7.5 mg/Kg (AT in AMS). Mean diameter of inhibition zone, 28.39 ± 2.07 mm produced by AT did not vary significantly (P > 0.05) from 26.36 ± 2.05 mm produced by AT in AMS. However, mean Salmonella gallinarum culture forming units per ml of bile, 17.6 ± 11 × 105of the untreated chicks and 3.4 ± 0.81 × 105(80.58% reduction), 2.4 ± 0.67 × 105(85.70% reduction), 5.4 ± 1.93 × 105(69.20% reduction ) and 0.38 ± 0.13 × 105(97.80% reduction ) of the respective treated groups, showed AMS significantly (P S. gallinarum infection, in vivo.