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R. Sablé-Fourtassou, P. Cohen, A. Mahr, C. Pagnoux, L. Mouthon, D. Jayne, D. Blockmans, J. F. Cordier, P. Delaval, X. Puechal, D. Lauque, J. F. Viallard, A. Zoulim, L. Guillevin, “The French Vasculitis Study Group. Antineutrophil Cytoplasmic Antibodies and the Churg-Strauss Syndrome,” Annals of Internal Medicine, Vol. 143, No. 9, 2005, pp. 632-638.

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• TITLE: Patient with Churg Strauss Syndrome and Myocarditis Treated with Cyclophosphamide

  AUTHORS: Liam Mullen, Janice Harper, Sukumaran Binukrishnan

  KEYWORDS: Cardiac MRI; Cyclophosphamide; Myocarditis; Churg Strauss Syndrome

  JOURNAL NAME: Open Journal of Nephrology, Vol.2 No.3, September 26, 2012

  ABSTRACT: Cardiac involvement in Churg Strauss Syndrome is common and a poor prognostic indicator. Myocarditis in Churg Strauss Syndrome can present in different ways. It has been shown that basic cardiac investigations including echocardiography can be normal even in symptomatic patients. More recently cardiac magnetic resonance imaging (MRI) has been shown to be more sensitive in its diagnosis. Our case report describes a 45 year old male who presented with palpitations and breathlessness. Echocardiography was normal but cardiac MRI demonstrated abnormalities consistent with Myocarditis. He was treated with Cyclophosphamide and follow up MRI imaging demonstrated complete resolution of these abnormalities which was accompanied by resolution of symptoms. This case therefore supports the use of cardiac MRI in Churg Strauss Syndrome as a sensitive diagnostic tool in and as a means of monitoring response to therapy. It also supports the therapeutic effectiveness of Cyclophosphamide therapy in Churg Strauss related Myocarditis, something that has yet to be assessed on a large scale.