TITLE:
Do We Have a Biocompatible Peritoneal Dialysis Fluid?
AUTHORS:
Shadi Hassan, Batya Kristal, Khalid Khazim, Fadi Hassan, Dunia Hassan, Kamal Hassan
KEYWORDS:
Icodextrin; Amino Acids PDF; Homocyteine; Carbohydrates; Lipids; Inflammation
JOURNAL NAME:
Open Journal of Nephrology,
Vol.2 No.3,
September
26,
2012
ABSTRACT: Objective: Cardiovascular disease remains the leading cause of morbidity and mortality in patients on maintenance dialysis. Diabetes mellitus, dyslipidemia, hypertension, inflammation and hyperhomocyteinemia are major cardiovascular risk factors. Aim: to evaluate the effects of Icodextrin and amino acid peritoneal dialysis fluid (AAPDF) on these major cardiovascular risk factors looking for a more biocompatible PDF formula. Methods: 24 adult stable peritoneal dialysis patients were included in the study. 12 patients received 2L Icodextrin and other 12 patients received 2L AAPDF in their dialysis prescription for 8 weeks. Results: Icodextrin decreased fasting plasma glucose (p Conclusions: A biocompatible PDF should provide not only adequate dialysis and ultrafiltration but should also improve nutritional and metabolic status, blood pressure control and reduce inflammation and plasma homocyteine.