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Kook, S.H., Son, Y.O., Choe, Y., Kim, J.H., Jeon, Y.M., Heo, J.S., Kim, J.G. and Lee, J.C. (2009) Mechanical force augments the anti-osteoclastogenic potential of hu- man gingival fibroblasts in vitro. Journal of Periodontal Research, 44, 402-410. doi:10.1111/j.1600-0765.2008.01121.x

has been cited by the following article:

• TITLE: Interleukin-1α and tumor necrosis factor-α expression on the compressed side of gingiva during orthodontic tooth movement

  AUTHORS: Hyoung-Seon Baik, Chong-Kwan Kim, Won Hee Lim, Youn Sic Chun

  KEYWORDS: Tooth Movement; Gingiva; Compressed Side; IL-1α; TNF-α

  JOURNAL NAME: Open Journal of Stomatology, Vol.2 No.3, September 27, 2012

  ABSTRACT: Objectives: The aim of this study was to investigate the effect of orthodontic loading on the expression of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in compressed gingiva. Materials and Methods: Twenty-four male Wistar rats were used with four rats as controls at day 0. In ten rats, corticotomy was performed on either left or right side and the re-maining side was served as control, and killed at 7 and 14 days. In the remaining ten rats, maxillary right and left first molars were moved orthodontically with a constant force of 20 g; appliance and appliance in conjunction with cortictomy (appliance-corticotomy) were sequentially alternated between left and right sides and euthanized at 7 and 14 days. Real time polymerase chain reactions of compressed gingiva excised from the euthanized rats was performed to measure mRNA expressions of IL-1α and TNF-α. Results: There were no significant differences in the expression of IL-1α between all the groups. On the other hand, TNF-α from the pressure side in the ap- pliance group and the appliance in conjunction with corticotomy group showed significant increase on the 7th day compared to that of either control or corticotomy group. Conclusions: Orthodontic loading induced the elevation of TNF-α in compressed gingiva