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Mabry, R.J., Shelburne, J. and Cohen, H.J. (1977) In vitro kinetics of immunoglobulin synthesis and secretion of non-secretory human myeloma cells. Blood, 50, 1031-1038.

has been cited by the following article:

• TITLE: Non-secretory multiple myeloma with lytic bone lesions about a new observation

  AUTHORS: M. El Euch, F. Ben Fredj Ismail, A. Rezgui, M. Karmani, F. Derbali, R. Amri, C. Laouani-Kechrid

  KEYWORDS: Non-Secretory Myeloma; Immunoglobulin; Hypercalcemia; Anemia; Lytic Bone Lesions

  JOURNAL NAME: Open Journal of Internal Medicine, Vol.2 No.3, September 27, 2012

  ABSTRACT: Non-secretory myeloma is a rare variety of multiple myeloma. Classical techniques of chronic secretion’s research don’t find any immunoglobulin monoclonal peak in the patient’s blood. Lytic bone lesions are rare in this type of myeloma. We report the case of a patient in whom we confirmed multiple myeloma by bone marrow aspiration and we have classified stage III of Durie and Salmon in view of hypercalcemia, anemia, and lytic lesions observed. However, we could not isolate a secretion of monoclonal immunoglobulin in blood but urinary secretion was evident by proteinuria and urinary light chains. The radiographs of our patient found diffuse osteolysis and practice of sternal puncture confirmed multiple myeloma. Our case is original because of rarity on non secretory myeloma particularly with diffuse osteolytic lesion.