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A. Nakamura, H. Wada, M. Ikejiri, T. Hatada, H. Sakurai, Y. Matsushima, J. Nishioka, K. Maruyama, S. Isaji, T. Takeda and T. Nobori, “Efficacy of Procalcitonin in the Early Diagnosis of Bacterial Infections in a Critical Care Unit,” Shock, Vol. 31, No. 6, 2009, pp. 586-591. doi:10.1097/SHK.0b013e31819716fa

has been cited by the following article:

• TITLE: Serum Procalcitonin and Neutrophil Toxic Granules Guided Management of Post-Operative K. pneumoniae Septic-Shock in Laminectomy—A Case Report

  AUTHORS: Indira Chivukula, Paul K. Marx, Kamaraju S. Ratnakar, G. Subbaiah, Venkataraman Sritharan

  KEYWORDS: Sepsis; Procalcitonin; Toxic Granules

  JOURNAL NAME: Advances in Infectious Diseases, Vol.2 No.3, September 27, 2012

  ABSTRACT: Introduction: We still rely on clinical diagnosis for initiating empirical antibiotic therapy and await blood culture for confirmation of infection, species identification and drug sensitivity. Differential blood cell count (WBC and neutrophils) and recording of toxic granules in the neutrophils are established methods for indirect diagnosis of infection though they are not used in the diagnosis of sepsis per se. Serum Procalcitonin is considered as a good biomarker in the management of sepsis. Materials and Methods: Whole blood and serum were used for laboratory analysis. We have combined the detection of toxic granules in the peripheral blood smear and serum PCT levels for diagnosis and monitoring the recovery of a patient with septic shock. A 63 year old laminectomy patient was transferred 2 days after the surgery to our hospital with several co-morbidities and complications. He was in septic shock and was put on Continuous Renal Replacement Therapy, with ionotropic support and IV fluids via nasogastric feeding and administration of Activated Protein C. Blood culture and daily measurements of serum Procalcitonin, differential blood cells count, and observation of toxic granules in neutrophils were done. Results: The blood culture showed infection due to K. pneumoniae resistant to carbapenems. WBC and Neutrophil counts were quite variable and showed incoherent response to treatment. Serum PCT was 24.57 ng/mL on the next day of admission and it peaked at 30.2 ng/mL on day 3. Its level started decreasing from the 4th day. Toxic granules disappeared when serum PCT levels reached