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I. Kostova, I. Manolov, S. Konstantinov and M. Karaivanova, “Synthesis, Physicochemical Characterisation and Cytotoxic Screening of New Complexes of Cerium, Lanthanum and Neodymium with Warfarin and Coumachlor Sodium Salts,” European Journal of Medicinal Chemistry, Vol. 34, No. 1, 1999, pp. 63-68.

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• TITLE: Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity

  AUTHORS: Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel

  KEYWORDS: Transition Metal Complex; Ciprofloxacin; Biological Activity

  JOURNAL NAME: Open Journal of Metal, Vol.2 No.3, September 4, 2012

  ABSTRACT: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.