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M. Noutsias, C. Hohmann, M. Pauschinger, P.-L. Schwimmbeck, K. Ostermann, U. Rode, et al., “sICAM-1 Correlates with Myocardial ICAM-1 Expression in Dilated Cardiomyopathy,” International Journal of Cardiology, Vol. 91, No. 2, 2003, pp. 153-161. doi:10.1016/S0167-5273(03)00033-0

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• TITLE: Anti Inflammatory Effects of Statins in Cardiac Surgery Patients

  AUTHORS: A. Raza, S. Kennedy, Y. Fan, B. Maher, M. Codd, T. Murphy, A. Wood, W. Watson

  KEYWORDS: Statins; Neutrophils; Cardiac Surgery; Outcome; TNF-α; sICAM-1

  JOURNAL NAME: World Journal of Cardiovascular Surgery, Vol.2 No.3, September 21, 2012

  ABSTRACT: Objectives: Cardiac surgery with cardiopulmonary bypass provokes systemic inflammatory response, which may cause organ dysfunction. Studies have suggested that pre-operative statin therapy can reduce morbidity and mortality associated with cardiac surgery; the mechanism for this remains unclear. We hypothesise that underlying mechanism of action for these effects of statins is through inhibition of neutrophil transendothelial migration. Methods: We recruited 151 patients undergoing cardiac surgery. Of these 41 patients were on no-statin; 48 patients on low-dose (10 - 30 mg) and 62 patients were on high-dose statin (40 - 80 mg). Ex vivo neutrophil migration was performed on pre-operative blood samples of 90 patients. Of these 90 patients we used 36 patients to assess the levels of TNF-α and sICAM-1. Clinical parameters of total 151 patients were assessed to analyse outcome. Results: Ex vivo neutrophil migration was decreased in high-dose statin group when compared to neutrophils isolated from no-statin or low-dose statin groups (p