TITLE:
Anti Inflammatory Effects of Statins in Cardiac Surgery Patients
AUTHORS:
A. Raza, S. Kennedy, Y. Fan, B. Maher, M. Codd, T. Murphy, A. Wood, W. Watson
KEYWORDS:
Statins; Neutrophils; Cardiac Surgery; Outcome; TNF-α; sICAM-1
JOURNAL NAME:
World Journal of Cardiovascular Surgery,
Vol.2 No.3,
September
21,
2012
ABSTRACT: Objectives: Cardiac surgery with cardiopulmonary bypass provokes systemic inflammatory response, which may cause organ dysfunction. Studies have suggested that pre-operative statin therapy can reduce morbidity and mortality associated with cardiac surgery; the mechanism for this remains unclear. We hypothesise that underlying mechanism of action for these effects of statins is through inhibition of neutrophil transendothelial migration. Methods: We recruited 151 patients undergoing cardiac surgery. Of these 41 patients were on no-statin; 48 patients on low-dose (10 - 30 mg) and 62 patients were on high-dose statin (40 - 80 mg). Ex vivo neutrophil migration was performed on pre-operative blood samples of 90 patients. Of these 90 patients we used 36 patients to assess the levels of TNF-α and sICAM-1. Clinical parameters of total 151 patients were assessed to analyse outcome. Results: Ex vivo neutrophil migration was decreased in high-dose statin group when compared to neutrophils isolated from no-statin or low-dose statin groups (p