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J. S. Pober, M. A. Gimbrone Jr., L. A. Lapierre, D. L. Mendrick, W. Fiers, R. Rothlein and T. A. Springer, “Overlapping Patterns of Activation of Human Endothelial Cells by Interleukin 1, Tumor Necrosis Factor, and Immune Interferon,” Journal of Immunology, Vol. 137, No. 6, 1986, pp. 1893-1896.

has been cited by the following article:

• TITLE: Anti Inflammatory Effects of Statins in Cardiac Surgery Patients

  AUTHORS: A. Raza, S. Kennedy, Y. Fan, B. Maher, M. Codd, T. Murphy, A. Wood, W. Watson

  KEYWORDS: Statins; Neutrophils; Cardiac Surgery; Outcome; TNF-α; sICAM-1

  JOURNAL NAME: World Journal of Cardiovascular Surgery, Vol.2 No.3, September 21, 2012

  ABSTRACT: Objectives: Cardiac surgery with cardiopulmonary bypass provokes systemic inflammatory response, which may cause organ dysfunction. Studies have suggested that pre-operative statin therapy can reduce morbidity and mortality associated with cardiac surgery; the mechanism for this remains unclear. We hypothesise that underlying mechanism of action for these effects of statins is through inhibition of neutrophil transendothelial migration. Methods: We recruited 151 patients undergoing cardiac surgery. Of these 41 patients were on no-statin; 48 patients on low-dose (10 - 30 mg) and 62 patients were on high-dose statin (40 - 80 mg). Ex vivo neutrophil migration was performed on pre-operative blood samples of 90 patients. Of these 90 patients we used 36 patients to assess the levels of TNF-α and sICAM-1. Clinical parameters of total 151 patients were assessed to analyse outcome. Results: Ex vivo neutrophil migration was decreased in high-dose statin group when compared to neutrophils isolated from no-statin or low-dose statin groups (p