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G. Hinkal and Donehower, “How Does Supression of IGF-I Signaling by DNA Damage Affect Aging and Longevity,” Mechanisms of Ageing and Development, Vol. 129, No. 5, 2008, pp. 243-253.

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• TITLE: Growth Hormone Prevents the Memory Deficit Caused by Oxidative Stress in Early Neurodegenerative Stage in Rats

  AUTHORS: Diana Verónica Castillo-Padilla, Gabino Borgornio-Pérez, Alejandro Zentella-Dehesa, Adrian Sandoval-Montiel, José Luis Ventura Gallegos, Selva Rivas-Arancibia

  KEYWORDS: Oxidative Stress; Growth Hormone; Insulin Growth Factor; Ozone, Serine-Threonine Protein Kinase; Water Maze; Passive Avoidance

  JOURNAL NAME: Neuroscience and Medicine, Vol.3 No.3, September 21, 2012

  ABSTRACT: Oxidative stress has been involved in neurodegenerative diseases. The growth hormone (GH) counteracts the levels of reactive oxygen species. Previously, we showed that the prolonged exposure to ozone causes oxidative stress in the hippocampus and memory deficits. In this work, we analyzed the effects of the growth hormone on the memory deficit generated by ozone exposure, growth hormone effects on the Insulin-like growth factor I (IGF-I), and the serinethreonine protein kinase (Akt) activation in the dentate gyrus. Our results show that GH prevents memory deficits in early stages of the neurodegenerative process.