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R. H. Breuer, A. Pasic, E. F. Smit, E. van Vliet, A. Vonk Noordegraaf, E. J. Risse, P. E. Postmus and T. G. Sutedja, “The Natural Course of Preneoplastic Lesions in Bronchial Epithelium,” Clinical Cancer Research, Vol. 11, No. 2, 2005, pp. 537-543.

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• TITLE: Effect of Impaired Lung Function on the Development and Progression of Endobronchial Premalignant Lesions

  AUTHORS: Vijayvel Jayaprakash, Gregory M. Loewen, Martin C. Mahoney, Samjot Dhillon, Sai Yendamuri, D. Kyle Hogarth, Enrique Machare-Delgado, Ravi J. Menezes, Sandra M. Jacob, Mary E. Reid

  KEYWORDS: COPD; Lung Cancer; Premalignant Lesions; Dysplasia; Pulmonary Function Test; Spirometry

  JOURNAL NAME: Journal of Cancer Therapy, Vol.3 No.4A, September 12, 2012

  ABSTRACT: Background: Chronic obstructive pulmonary disease (COPD) and presence of endobronchial premalignant lesions (EPL) are individual risk factors for lung cancer (LC). However, effect of impaired lung function (ILF) on the natural history of EPL has not been explored. Patients and Methods: This study included 217 high-risk participants from a hospital-based LC surveillance cohort who underwent pulmonary function testing followed by bronchoscopy with endobronchial biopsies. Baseline histopathology diagnoses included 91 cases (41.9%) with squamous metaplasia (SM), 25 (11.5%) with squamous dysplasia (SD), 1 (0.5%) with in-situ carcinoma and 5 (2.3%) with invasive LC. Follow-up biopsies were obtained for 69 patients, and 16 (23.2%) patients demonstrated progression to a higher grade lesion. Regression models were used to evaluate the relationship between ILF and EPL. All the models were adjusted for age, gender and tobacco smoking. Results: Patients with FEV1% of