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S. Moir, A. Malaspina, K. M. Ogwaro, E. T. Donoghue, C. W. Hallahan, L. A. Ehler, S. Liu, J. Adelsberger, R. Lapointe, P. Hwu, M. Baseler, J. M. Orenstein, T. W. Chun, J. A. Mican and A. S. Fauci, “HIV-1 Induces Phenotypic and Functional Perturbations of B Cells in Chronically in Fected Individuals,” Proceedings of the National Academy of Sciences of the USA, Vol. 98, No. 18, 2001, pp. 10362-10367. doi:10.1073/pnas.181347898

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• TITLE: Levels of Immunoglobulin Classes Are Not Associated with Severity of HIV Infection in Nigerian Patients

  AUTHORS: Oluwaseun O. Akinpelu, Yetunde A. Aken'Ova, O. Ganiyu Arinola

  KEYWORDS: HIV; Immunoglobulins

  JOURNAL NAME: World Journal of AIDS, Vol.2 No.3, September 24, 2012

  ABSTRACT: The serum concentrations of immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), total protein and albumin were measured in 35 Human Immunodeficiency Virus—positive, HAART (highly active antiretroviral therapy) na?ve subjects attending the PEPFAR (President's Emergency Plan for AIDS relief) clinic, University College Hospital, Ibadan and in 30 apparently healthy control subjects to assess the relationship between serum protein, immunoglobulin concentrations and laboratory indices of HIV disease (CD4 cell counts and viral load). Serum IgG (1008.6 ± 530.7 mg/dl), IgA (170.4 ± 69 mg/dl) and total protein (9.9 ± 1.7 g/dl) levels were higher among HIV positive subjects compared with mean values in healthy subjects (549.8 ± 193.8 mg/dl, 106.8 ± 26.4 mg/dl and 7.8 ± 0.5 g/dl respectively). The median serum IgM concentration (131mg/dl) was significantly higher in HIV positive subjects compared with 35 mg/dl in healthy controls (p 200 cells/μL. There was also no statistically significant correlation observed between viral load and serum immunoglobulin levels.