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Bujold, E., Roberge, S., Lacasse, Y., Bureau, M., Audibert, F., Marcoux, S., et al. (2010) Prevention of pre-eclampsia and intrauterine growth restriction with aspirin started in early pregnancy: A meta-analysis. Obstetrics & Gynecology, 116, 402-414. doi:10.1097/AOG.0b013e3181e9322a

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• TITLE: The diagnostic accuracy of the usage of the Fetal Medicine Foundation’s (FMF) on-line risk calculator with first-trimester ultrasound for screening for preeclampsia in high-risk pregnant Brazilian population

  AUTHORS: Ernesto Antonio Figueiró-Filho, Maithe Vendas Galhardo, Bruno Areco de Souza

  KEYWORDS: Accuracy; Sensitivity; Specificity; Preeclampsia; First Trimester; Risk

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.2 No.3, September 7, 2012

  ABSTRACT: To evaluate the sensitivity and specificity of the usage of the FMF On-Line Risk Calculator with first-trimester ultrasound, in screening assessment for preeclampsia (PE), without serum markers. To define the best risk cut-off values for early, intermediate and late preeclampsia. Diagnostic accuracy study of pregnant women who had first-trimester ultrasounds between 11 and 13 weeks. The index test was the first-trimester ultrasound scan plus the FMF On-Line Risk Calculator to assess the risk for PE. The reference standard was the confirmation of actual development of early, intermediate or late PE. For calculations of sensitivity and specificity to determine the best cut-off values for early, intermediate and late PE, all the information was processed into ROC curves. The assessment of preeclampsia risk in the first trimester using an ultrasound plus the FMF On-Line Risk Calculator demonstrated a significant (p