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Loughrey, J.P.R., Yao, N., Datta, S., Segal, S., Pian-Smith, M. and Tsen, L.C. (2005) Hemodynamic effects of spinal anesthesia and simultaneous intravenous bolus of combined phenylephrine and ephedrine versus ephedrine for cesarean delivery. International Journal of Obstetric Anesthesia, 14, 43-47. doi:10.1016/j.ijoa.2004.07.011

has been cited by the following article:

• TITLE: Comparison the effect of ephedrine and phenylephrine in treatment of hypotension after spinal anesthesia during cesarean section

  AUTHORS: Atashkhoyi Simin, Fardiazar Zahra, Hatami Marandi Pouya, Torab Reza

  KEYWORDS: Cesarean Section; Spinal Anesthesia; Hypotension; Ephedrine; Phenylephrine; Fetal/Neonatal Outcome

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.2 No.3, September 7, 2012

  ABSTRACT: Background and Objective: The effectiveness of ephedrine and/or phenylephrine, in treatment of hypotension secondary to spinal anesthesia for cesarean section and their effects on fetal/neonatal outcome were studied. Methods and Materials: Sixty healthy parturients were randomly assigned to two groups; group E (n = 33) received boluses 5 mg/ml increments ephedrine and group P (n = 27) received a boluses of phnylephrine 100 μg/ml increments for treatment of hypotension after spinal block during cesarean section. Changes in maternal blood pressure and heart rate, and incidence of nausea-vomiting, neonatal Apgar score at 1 and 5 minutes of delivery, and umbilical arterial blood gas values were recorded. Results: There were no differences in treatment of hypotension following sympathectomy after spinal block with two drugs. Neonatal outcome was similar in two groups. There were not significant differences in umbilical arterial values in two groups. Conclusion: Ephedrine and phenylephrine are both effective vasopressores for treatment of hypotension associated to spinal block during cesarean section without adverse effects on infants/neonates.