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• TITLE: Effects of Baicalin and Ligustrazine on airway inflammation and remodeling and underlying mechanism in asthmatic rats

  AUTHORS: Shi-man Wu, Hai-Yan Wu, Yong-jie Wu, Li Liu, Ren-ping Cai, Yong-jian Xu

  KEYWORDS: Asthma; Airway Remodeling; Airway Inflammation; Baicalin; Ligustrazine

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.3 No.5, September 21, 2012

  ABSTRACT: Aim: To explore the effects of Baicalin and Ligustrazine on airway inflammation and construction and underlying mechanisms through the expressions of GATA-3, IL-5, MMP-9 and TIMP-1 in asthmatic rats. Methods: 30 Wistar rats were randomly divided equally into five groups. Lung tissues were sliced. WBC and Eos in lung tissue were estimated by HE stain and the expressions of IL-5, GATA-3, MMP-9, TIMP-1 and collagen type IV in lung tissue were observed by immunohistochemistry. The airway wall and airway smooth muscle thicknesses were measured by computed image analysis system. Results: Compared with asthma group, EOS counts and the expression of IL-5 and GATA-3 in the lung tissue were significantly lower in normal controlled groups (P Baicalin or Ligustrazine, EOS decreased, and the thicknesses of airway wall and airway smooth muscle became thinner compared with asthma group. Meanwhile, the expression of collagen type IV, IL-5, GATA-3, MMP-9 and TIMP-1 significantly decreased (P