Article citationsMore>>

Abdalla, C.M., de Oliveira, Z.N., Sotto, M.N., Leite, K.R., Canavez, F.C. and de Carvalho, C.M. (2009) Polymerase chain reaction compared to other laboratory findings and to clinical evaluation in the diagnosis of cutaneous tuberculosis and atypical mycobacteria skin infection. International Journal of Dermatology, 48, 27-35. doi:10.1111/j.1365-4632.2009.03807.x

has been cited by the following article:

• TITLE: Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: A case report

  AUTHORS: Bruna Daniella de Souza Silva, Sueli Lemes de Ávila Alves, André Kipnis, Ana Paula Junqueira-Kipnis

  KEYWORDS: Cutaneous tuberculosis; Late Diagnosis; CD8+ T Cells

  JOURNAL NAME: Open Journal of Immunology, Vol.2 No.3, September 21, 2012

  ABSTRACT: Introduction: Cutaneous tuberculosis (CTB) is a rare form of extra-pulmonary tuberculosis that, when associated with late diagnosis, worsen the quality of life of the sick individuals. This report presents a case of late diagnosis of CTB. Unusual clinical manifestations retarded the correct tuberculosis diagnosis for more than a year. The immune response elicited by this type of tuberculosis as well as the factors that might contribute to the delay in diagnosis was evaluated and discussed. Methodology: Clinical evaluation and flow cytometric analyses of PBMC were realized for a case of CTB and a healthy individual as a control. Results: M. tuberculosis specific TCD8+ cell response was analyzed by flow cytometry and revealed positive cells for IL-17, IL-10, TGF-β and IDO. The CTB patient presented higher percentage of those cells when compared to a healthy donor. However, TCD8 cells positive for the important protective cytokine, IFN-γ was decreased in the CTB patient. Conclusion. The assessment of the M. tuberculosis specific TCD8+ immune response showed a regulatory/modulatory phenotype with a reduced IFN-γ response when compared to the healthy control that could have contributed to the CTB infection.