Article citationsMore>>

Voyich, J.M., Otto, M., Mathema, B., Braughton, K.R., Whitney, A.R., Welty, D., Long, R.D., Dorward, D.W., Gardner, D.J., Lina, G., Kreiswirth, B.N., DeLeo, F.R. (2006) Is panton-valentine leukocidin the major virulence determinant in community-associated methicillin-resis-tant staphylococcus aureus disease? Journal of Infectioius Diseases, 194, 1761-1770. doi:10.1086/509506

has been cited by the following article:

• TITLE: Identification of a T-cell epitope in the Staphylococcus aureus Panton-Valentine LukS-PV component

  AUTHORS: Eric L. Brown, Keri Csencsits Smith, Maria Gabriela Bowden

  KEYWORDS: Staphylococcus; Cell Mediated Immunity; Panton-Valentine Leukocidin; T Cells

  JOURNAL NAME: Open Journal of Immunology, Vol.2 No.3, September 21, 2012

  ABSTRACT: We previously observed the elicitation of a significant delayed-type hypersensitivity response to the Panton-Valentine leukocidin (PVL) LukS-PV subunit following subcutaneous immunization (Brown et al., Clinical Microbiology and Infection, 2009, 156: 156-164). A LukS-PV-specific cell line (LST) was screened for proliferative responses against a panel of 25 amino acid-long peptides spanning the length of LukS-PV (amino acids 29-312). This analysis demonstrated that stimulation of LST with LukS-PV resulted in significant proliferative responses and adoptive transfer of LST into na?ve mice conferred a LukS-PV-specific DTH response following challenge. Challenge of mice adoptively transferred with LST with peptides 7 (149-173), 8 (169-193) and 14 (289-312) also elicited a measurable DTH response suggesting that these peptides contained T cell epitopes.