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Sauer, M.V., Paulson, R.J. and Lobo, R.A. (1992) Reversing the natural decline in human fertility. An extended clinical trial of oocytes donation to women of advanced reproductive age. Journal of the American Medical Association, 268(10), 1275-1279.

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• TITLE: Beneficial effect of reduced oxygen concentration with transfer of blastocysts in IVF patients older than 40 years old

  AUTHORS: Javier I. García, Soledad Sepúlveda, Luis Noriega-Hoces

  KEYWORDS: ART; Blastocyst; IVF; ICSI; Oxygen

  JOURNAL NAME: Health, Vol.2 No.9, September 29, 2010

  ABSTRACT: The aim of the present study was to determine the impact of oxygen concentration on implantation, pregnancy and delivery rates in IVF patients older than 40 year old with transfer of blastocysts. Included were 558 women aged 23-45 years old undergoing IVF/ICSI procedures whose embryos were cultured at blastocyst stage under two different oxygen environments (a bi-gas system: 5.6% CO2 in air and a tri-gas system: 5.6% CO2, 5% de O2 and 89.4% N2). The main outcome measures of this study are implantation, pregnancy and delivery rates. Implantation, pregnancy and delivery rates are found to be reduced in women older than 40 years old. The implantation and pregnancy rates are significantly higher in women older than 40 years old from the 5% of O2 group, in comparison to the 20% group (25.00% versus 2.70% and 41.38% versus 5.56%; P