TITLE:
Beneficial effect of reduced oxygen concentration with transfer of blastocysts in IVF patients older than 40 years old
AUTHORS:
Javier I. García, Soledad Sepúlveda, Luis Noriega-Hoces
KEYWORDS:
ART; Blastocyst; IVF; ICSI; Oxygen
JOURNAL NAME:
Health,
Vol.2 No.9,
September
29,
2010
ABSTRACT: The aim of the present study was to determine the impact of oxygen concentration on implantation, pregnancy and delivery rates in IVF patients older than 40 year old with transfer of blastocysts. Included were 558 women aged 23-45 years old undergoing IVF/ICSI procedures whose embryos were cultured at blastocyst stage under two different oxygen environments (a bi-gas system: 5.6% CO2 in air and a tri-gas system: 5.6% CO2, 5% de O2 and 89.4% N2). The main outcome measures of this study are implantation, pregnancy and delivery rates. Implantation, pregnancy and delivery rates are found to be reduced in women older than 40 years old. The implantation and pregnancy rates are significantly higher in women older than 40 years old from the 5% of O2 group, in comparison to the 20% group (25.00% versus 2.70% and 41.38% versus 5.56%; P