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H. Xiao and T. E. Edwards and A. R. Ferré-D’Amaré, “Structural Basis for Specific, High-Affinity Tetracycline Binding by an in Vitro Evolved Aptamer and Artificial Riboswitch,” Chemistry & Biology, Vol. 15, No. 10, 2008, pp. 1125-1137. doi:10.1016/j.chembiol.2008.09.004

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• TITLE: Aptasensors in Health, Environment and Food Safety Monitoring

  AUTHORS: Arghya Sett, Suradip Das, Pragya Sharma, Utpal Bora

  KEYWORDS: Aptamer; Biosensor; Clinical Diagnosis; Food Safety; Environmental Pollution Control

  JOURNAL NAME: Open Journal of Applied Biosensor, Vol.1 No.2, August 24, 2012

  ABSTRACT: Biosensors have been developed using various types of sensing elements like biomacromolecules (viz. enzymes, antibodies, receptors, nucleic acids, etc.) organelles, tissues, intact cells of both microorganisms and higher organisms. A recent trend is the emergence of aptamers as sensing elements that has the potential to replace all the above ligands. This is possible due to the unique features of aptamers (sensitivity, specificity, reusability, stability, non-immunogenic- ity), which can be easily exploited in biosensor technology. Aptasensors are thus basically biosensors based on aptamers as ligand molecules. Here we review the various applications of aptasensors in health (specifically in diagnostics), food industry and environmental monitoring.