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S. A. Mahesar, A. A. Kandhro, L. Cerretani, A. Bendini, S. T. H. Sherazi and M. I. Bhanger. “Determination of Total Trans Fat Content in Pakistani Cereal Based Foods by SB-HATR FT-IR Spectroscopy Coupled with Partial Least Square Regression,” Food Chemistry, Vol. 123, No. 4, 2010, pp. 1289-1293. doi:10.1016/j.foodchem.2010.05.101

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• TITLE: Simultaneous Quantification of Ibuprofen and Paracetamol in Tablet Formulations Using Transmission Fourier Transform Infrared Spectroscopy

  AUTHORS: Muhammad Ali Mallah, Syed Tufail Hussain Sherazi, Sarfaraz Ahmed Mahesar, Abdul Rauf Khaskheli

  KEYWORDS: Transmission FTIR; Pharmaceutical Formulation; Ibuprofen; Paracetamol; Simultaneous Determination; Quantitative Analysis

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.3 No.8, August 27, 2012

  ABSTRACT: A very simple, non-destructive, inexpensive and green strategy was applied for the simultaneous determination of ibu-profen (IBP) and paracetamol (PC) using transmission Fourier Transform Infrared (FTIR) spectroscopy in tablet formulations for routine quality control laboratories. For the determination of the active pharmaceutical ingredients (API), KBr pellets containing known amount of standards and samples were used for acquisition of the FTIR spectra. The partial least squares (PLS) calibration model was developed using the spectral region from 1781 - 1683 cm-1 for IBP and 1630 - 1530 cm-1 for PC. The excellent coefficients of determination (R2), 0.9999 and 0.9998 were achieved for IBP and PC, respectively. The accuracy of calibration model was also verified through root mean square error of cross validation (RMSECV) which was found to be 0.064. This work clearly shows the capability of transmission FTIR spectroscopy for assessment of exact quantity of API to control the quality of finished products as well as during processing in pharmaceutical industries without involvement of any solvent.