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• TITLE: Adjuvant effect of a synthetic Aluminium-Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei

  AUTHORS: Maduike C. O. Ezeibe, Nnenna P. Elendu-Eleke, Obianuju N. Okoroafor, Augustine A. Ngene

  KEYWORDS: Antiplasmodial Resistance; Chloroquine Toxicity; Synthetic Aluminium-Magnesium Silicate

  JOURNAL NAME: Health, Vol.4 No.8, August 29, 2012

  ABSTRACT: Effect a synthetic Aluminium-Magnesium Silicate (AMS) has on chloroquine was tested. Thirty, Plasmodium berghei-infected mice, in three experimental groups (7 mg/kg, 5 mg/kg and 3 mg/kg) of 10 mice each, were treated. Two subgroups, in each experiment, were treated with chloroquine and with a chloroquine-AMS drug formulation, respectively. Five of the infected mice served as controls. Parasitaemia (%), Haemoglobin concentration (Hb), Red Blood Cells (RBC), rectal temperature and body weight were assessed. Parasitaemia of subgroups treated at 7 mg/kg were higher than that of the control. Also, at 7 mg/kg, there was mortality with chloroquine (20%) and with the chloroquine-AMS drug (80%). At 5 mg/kg and 3 mg/kg, the AMS significantly (P