TITLE:
Adjuvant effect of a synthetic Aluminium-Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei
AUTHORS:
Maduike C. O. Ezeibe, Nnenna P. Elendu-Eleke, Obianuju N. Okoroafor, Augustine A. Ngene
KEYWORDS:
Antiplasmodial Resistance; Chloroquine Toxicity; Synthetic Aluminium-Magnesium Silicate
JOURNAL NAME:
Health,
Vol.4 No.8,
August
29,
2012
ABSTRACT: Effect a synthetic Aluminium-Magnesium Silicate (AMS) has on chloroquine was tested. Thirty, Plasmodium berghei-infected mice, in three experimental groups (7 mg/kg, 5 mg/kg and 3 mg/kg) of 10 mice each, were treated. Two subgroups, in each experiment, were treated with chloroquine and with a chloroquine-AMS drug formulation, respectively. Five of the infected mice served as controls. Parasitaemia (%), Haemoglobin concentration (Hb), Red Blood Cells (RBC), rectal temperature and body weight were assessed. Parasitaemia of subgroups treated at 7 mg/kg were higher than that of the control. Also, at 7 mg/kg, there was mortality with chloroquine (20%) and with the chloroquine-AMS drug (80%). At 5 mg/kg and 3 mg/kg, the AMS significantly (P