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Nakasa, H., Komiya, M., Ohmori, S., Rikihisa, T., Tiuchi, M. and Kitada, M. (1993) Characterization of human liver microsomal cytochrome P450 involved in the reductive metabolism of zonisamide. Molecular Pharmacology, 44, 216-221.

has been cited by the following article:

• TITLE: Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro

  AUTHORS: Ken-ichi Tanaka, Takeshi Nanba, Tomoyuki Furubayashi, Yasuko Noda, Luther James Willmore, Akitane Mori

  KEYWORDS: Zonisamide; Hydroxyl Radicals; LC/MS; ESR

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.3 No.3, August 28, 2012

  ABSTRACT: Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hydroxyl radicals, were analyzed by the LC/MS technique. Many small fragments were found in the both reactions, suggesting that ZNS was decomposed not only by hydroxyl radicals but also by hydrogen peroxide. Furthermore, mass-fragment-grams showed that m/z: 213 (ZNS itself) was decreased markedly and m/z: 118 (may be a decomposed product by ring cleavage of ZNS) was detected specifically by treatment with hydroxyl radical. These data suggested that ZNS may react directly with free radicals.