Article citationsMore>>

Ito, T., Yamaguchi, T., Miyazaki, H., Sekine, Y., Shimizu, M., Ishida, S., Yagi, K., Kakegawa, N., Seino, M. and Wada, T. (1982) Pharmacokinetic studies of AD-810, a new antiepileptic compound. Phase I trials. Arzneinmittelforsch, 32, 1581-1586.

has been cited by the following article:

• TITLE: Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro

  AUTHORS: Ken-ichi Tanaka, Takeshi Nanba, Tomoyuki Furubayashi, Yasuko Noda, Luther James Willmore, Akitane Mori

  KEYWORDS: Zonisamide; Hydroxyl Radicals; LC/MS; ESR

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.3 No.3, August 28, 2012

  ABSTRACT: Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hydroxyl radicals, were analyzed by the LC/MS technique. Many small fragments were found in the both reactions, suggesting that ZNS was decomposed not only by hydroxyl radicals but also by hydrogen peroxide. Furthermore, mass-fragment-grams showed that m/z: 213 (ZNS itself) was decreased markedly and m/z: 118 (may be a decomposed product by ring cleavage of ZNS) was detected specifically by treatment with hydroxyl radical. These data suggested that ZNS may react directly with free radicals.