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Rosen, G.M. and Rauckman, E.J. (1984) Spin trapping of superoxide and hydroxyl radicals. In: Packer, L., Ed., Methods in Enzymology, Oxygen Radicals in Biological Systems, Academic Press, San Diego, 198-209. doi:10.1016/S0076-6879(84)05026-6

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• TITLE: Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro

  AUTHORS: Ken-ichi Tanaka, Takeshi Nanba, Tomoyuki Furubayashi, Yasuko Noda, Luther James Willmore, Akitane Mori

  KEYWORDS: Zonisamide; Hydroxyl Radicals; LC/MS; ESR

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.3 No.3, August 28, 2012

  ABSTRACT: Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hydroxyl radicals, were analyzed by the LC/MS technique. Many small fragments were found in the both reactions, suggesting that ZNS was decomposed not only by hydroxyl radicals but also by hydrogen peroxide. Furthermore, mass-fragment-grams showed that m/z: 213 (ZNS itself) was decreased markedly and m/z: 118 (may be a decomposed product by ring cleavage of ZNS) was detected specifically by treatment with hydroxyl radical. These data suggested that ZNS may react directly with free radicals.