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D. Goldenberg, S. Harden, B. G. Masayesva, P. Ha, N. Benoit, W. H. Westra, W. M. Koch, D. Sidransky and J. A. Califano, “Intraoperative Molecular Margin Analysis in Head and Neck Cancer,” Archives of Otolaryngology—Head and Neck Surgery, Vol. 130, No. 1, 2004, pp. 39-44. doi:10.1001/archotol.130.1.39

has been cited by the following article:

• TITLE: Oral Squamous Cell Carcinoma: Epidemiology, Clinical Presentation and Treatment

  AUTHORS: Liviu Feller, Johan Lemmer

  KEYWORDS: Oral Squamous Cell Carcinoma; Epidemiology; Clinical Course; Field of Precancerization

  JOURNAL NAME: Journal of Cancer Therapy, Vol.3 No.4, August 9, 2012

  ABSTRACT: Squamous cell carcinoma accounts for 90% of all oral cancers. It may affect any anatomical site in the mouth, but most commonly the tongue and the floor of the mouth. It usually arises from a pre-existing potentially malignant lesion, and occasionally de novo; but in either case from within a field of precancerized epithelium. The use of tobacco and betel quid, heavy drinking of alcoholic beverages and a diet low in fresh fruits and vegetables are well known risk factors for oral squamous cell carcinoma. Important risk factors related to the carcinoma itself that are associated with a poor prognosis include large size of the tumour at the time of diagnosis, the presence of metastases in regional lymphnodes, and a deep invasive front of the tumour. Squamous cell carcinoma is managed by surgery, radiation, and chemotherapy singularly or in combination; but regardless of the treatment modality, the five-year survival rate is poor at about 50%. This can be attributed to the fact that about two-thirds of persons with oral squamous cell carcinoma already have a large lesion at the time of diagnosis.