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A. D. Rapidis, P. Gullane, J. D. Langdon, J. L. Lefebvre, C. Scully and J. P. Shah, “Major Advances in the Knowledge and Understanding of the Epidemiology, Aetiopathogenesis, Diagnosis, Management and Prognosis of Oral Cancer,” Oral Oncology, Vol. 45, No. 4, 2009, pp. 299-300. doi:10.1016/j.oraloncology.2009.04.001

has been cited by the following article:

• TITLE: Oral Squamous Cell Carcinoma: Epidemiology, Clinical Presentation and Treatment

  AUTHORS: Liviu Feller, Johan Lemmer

  KEYWORDS: Oral Squamous Cell Carcinoma; Epidemiology; Clinical Course; Field of Precancerization

  JOURNAL NAME: Journal of Cancer Therapy, Vol.3 No.4, August 9, 2012

  ABSTRACT: Squamous cell carcinoma accounts for 90% of all oral cancers. It may affect any anatomical site in the mouth, but most commonly the tongue and the floor of the mouth. It usually arises from a pre-existing potentially malignant lesion, and occasionally de novo; but in either case from within a field of precancerized epithelium. The use of tobacco and betel quid, heavy drinking of alcoholic beverages and a diet low in fresh fruits and vegetables are well known risk factors for oral squamous cell carcinoma. Important risk factors related to the carcinoma itself that are associated with a poor prognosis include large size of the tumour at the time of diagnosis, the presence of metastases in regional lymphnodes, and a deep invasive front of the tumour. Squamous cell carcinoma is managed by surgery, radiation, and chemotherapy singularly or in combination; but regardless of the treatment modality, the five-year survival rate is poor at about 50%. This can be attributed to the fact that about two-thirds of persons with oral squamous cell carcinoma already have a large lesion at the time of diagnosis.