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Inagaki, K. and Shimasaki, S. (2010) Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins with mutations in the proregion. Molecular and Cellular Endocrinology, 328, 1-7. doi:10.1016/j.mce.2010.05.017

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• TITLE: Genetics pathogenesis in the ovarian insufficiency

  AUTHORS: Lilliana Ciotta, Isabella Pagano, Vito Leanza, Mariagrazia Stracquadanio, Carlo Pafumi

  KEYWORDS: Premature Ovarian Failure; Hypergonadotropic Hypogonadism; Inhibitory Feedback

  JOURNAL NAME: Open Journal of Preventive Medicine, Vol.2 No.3, August 7, 2012

  ABSTRACT: Premature Ovarian Failure (POF) is a heterogeneous syndrome characterized by Hypergonadotropic Hypogonadism that affects about 1% of women younger than 40 years old, while an incidence of 1/1000 is reported in women younger than 30 years old. [1] This hormonal disorder is caused by the loss of the ovarian response towards the pituitary gonadrotropins synthesis (FSH and LH) that are secreted according to the inhibitory feedback between hypothalamus, pituitary gland and gonads.