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Tonetti, M.S., D Aiuto, F., Nibali, L., Danold, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A.D.,Vallance, P., Deanfield, J.(2007)Treatment of periodontitis and endothelial function. N Engl J Med,356,911-920.

has been cited by the following article:

• TITLE: Influence of periodontitis and nonsurgical periodontal intervention on atherosclerosis diseases

  AUTHORS: Tielou Chen, Shifeng Wang, Guoqin Liu, Xinhai Zhang, Dahai Tang, Zhifen Wu

  KEYWORDS: Atherosclerosis Diseases; Nonsurgical Periodontal Intervention; Periodontitis; Epithelial Function;C-Response Protein

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.3 No.4A, August 24, 2012

  ABSTRACT: Objective: Periodontitis and atherosclerosis diseases are chronic inflammatory disorders which are highly prevalent in populations. Nonsurgical periodontal intervention belongs to the initial therapy strategy to periodontal diseases. Periodontal pathogen can enter into blood stream through the ulceration epithelial resulting in bacteraemia when periodontitis is severe. The objective is to investigate the relationship between periodontitis and atherosclerosis diseases, and the influence of nonsurgical periodontal intervention on atheroma and atherosclerosis diseases. Methods: This study reviewed and analyzed the papers which published in the world associated with periodontitis or periodontal intervention on atherosclerosis diseases. Results: Periodontitis and periodontal infectious are important risk factors for atherosclerotic diseases. Much evidence has proved the durative severe periodontitis can result in bacteraemia and systemic inflammation, elevated C-response protein in serum, gingival microcirculation changed, periodontal microorganism reproduced, and endothelial dys-function and endocarditis. Nonsurgical periodontal intervention can remove the pathogenesis bacteria and calculus to recover periodontal health. Effective periodontal therapy can reduce bacteraemia and stop the hurt to vessels. Nonsurgical periodontal therapy may interfere periodontal bacteria, inhibit inflammation response and C-response protein, improving gingival microcirculation and vessel epithelial function to prevent atherosclerosis. Conclusion: Nonsurgical periodontal intervention can improve or decrease the rate of atherosclerotic disease by interfere the severe periodontitis. The detailed mechanism of periodontal intervention on atheroma and atherosclerotic disease is still need to be explored.