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Rubin JS, Day RM, Breckenridge D, Atabey N, Taylor WG, Stahl SJ, et al. Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling. J Biol Chem. 2001;276:32977-83.

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• TITLE: High concentration but low biological activity of hepatocyte growth factor in patients with chronic renal failure

  AUTHORS: Johanna Lönn, Faisal Shahzad, Fredrik Uhlin, Torbjörn Bengtsson, Gabriel Almroth, Fariba Nayeri

  KEYWORDS: Chronic Renal Failure; Hepatocyte Growth Factor; Biological Activity; Neutrophils

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.3 No.4A, August 24, 2012

  ABSTRACT: Hepatocyte growth factor (HGF) is a renotropic, antifibrotic and regenerative factor with cytoprotective effects that is produced by mesenchymal cells and shows high affinity to components of extra cellular matrix, such as heparan sulphate proteoglycan (HS-PG), in healthy. Patients with chronic renal failure (CRF) suffer from a chronic inflammatory disorder. In order to assess the underlying mechanisms for development of CRF we aimed to assess the amounts and affinity of HGF in this patient group. Elisa, western blot and surface plasmon resonance (SPR) were used to study HGF in blood samples, as well as in isolated neutrophils, in CRF patients compared to healthy controls. Patients with CRF showed higher HGF levels in serum (P P