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Friedewald, W.T., Levy, R.I., Fredrickson, D.S (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin ChemJun 18(6): 499-502.

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• TITLE: Hydroperoxides and cytokines as biomarkers in detecting atherosclerosis predisposition in cigarette smokers

  AUTHORS: Valter Lubrano, Michela Ballardin, Vincenzo Longo, Moreno Paolini, Roberto Scarpato

  KEYWORDS: IL-6; TNFα; CRP; Hydroperoxides; Ossidative Stress; CAD

  JOURNAL NAME: Modern Research in Inflammation, Vol.1 No.1, August 23, 2012

  ABSTRACT: Objectives: Smoking increases oxidative modification of LDL, associated with lower HDL plasma levels, systemic inflammatory response and endothelial dysfunction. We tested the hypothesis that the risk status for coronary atherosclerosis disease (CAD) of cigarettes smokers might be identified by means of serum oxidative levels and vascular inflammation determination. Design and Methods: Oxidative stress levels, cytokines, and the metabolic status were investigated on 499 subjects admitted to our institute. The association between biomarkers and smoking habits in the presence/absence of disease and with the number of vessel affected, was studied. Results: Oxidative stress and inflammatory levels (p