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Kraaier, V., Van Huffelen, A.C. and Wieneke, G.H. (1989) The hyperventilation-induced ischaemia model in human neuropharmacology: Neurophysiological and psychometric studies of aniracetam and 3-OH aniracetam. European Journal of Clinical Pharmacology, 36, 605-611. doi:10.1007/BF00637744

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• TITLE: The use of DCEEG to estimate functional and metabolic state of nervous tissue of the brain at hyper- and hypoventilation

  AUTHORS: Sergey Murik

  KEYWORDS: DCEEG; Full-Band EEG (fbEEG); Functional State of the Nervous Tissue; Hyperventilation; Hypoventilation; Breath Holding; Ischemia

  JOURNAL NAME: World Journal of Neuroscience, Vol.2 No.3, August 23, 2012

  ABSTRACT: A pilot study has been made of the simultaneous DC potential and total slow electrical activity changes during modeling various metabolic and functional states of the human brain. The multi-electrode DCEEG recordings have been performed during the hyperventilation (frequent deep one-minute long breathing motions) and the hypoventilation (voluntary breath holding). It has been shown that the ischemic state occurring in hyperventilation is accompanied by the negative shift of DC potential and increase in the EEG rhythms amplitude. A distention of brain vessels during hypoventilation (voluntary breath-hold) and an improvement of blood supply and thus improvement of vital and functional state of neurons gave rise to an increase in the EEG rhythm amplitude too, though against a background of a positive DC-potential shift. Obtained results are considered with context the generation of the qualitatively different functional states of brain cells during hyper- and hypoventilation which is reflected in their resting potential and activity. The conducted study show the prospects for DCEEG and the method we used for DCEEG data processing to understand the character of functional and metabolic changes in the nervous tissue.