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Bain, J.D., Diala, E.S., Glabe, C.G., et al. (1991) Chamberlin AR. Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semisynthetic aminoacyl-tRNAs. Biochemistry, 30, 5411-5421. doi:10.1021/bi00236a013

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• TITLE: Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons

  AUTHORS: Zixian Lu

  KEYWORDS: Nonsense Suppression; Codon Nonsense Mutation; Suppressor tRNAs

  JOURNAL NAME: Advances in Biological Chemistry, Vol.2 No.3, August 23, 2012

  ABSTRACT: Codon nonsense mutations include amber, ochre, or opal mutations according to termination codon consisting of three types (TAG, TAA and TGA). Codon nonsense mutations are also divided into natural and artificial mutations. We discussed the interaction of codon nonsense mutations and suppressor tRNAs in vitro and in vivo. Nonsense suppressions do not only happen in prokaryotes but also in eukaryotes. Meanwhile, the misreading of termination codon and in-corporation of nonnatural amino acids into proteins are also introduced.