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Isaksson K, Akerberg D, Andersson R, Tingstedt B. (2010) Toxicity and dose response of intra-abdominally administered poly-L-alpha-lysine and poly-L-glutamate for postoperative adhesion protection. Eur Surg Res, 44, 17-22.

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• TITLE: The influence on abdominal adhesions and inflammation in rabbits after exposure to differently charged polypeptides

  AUTHORS: Daniel Åkerberg, Carl Grunditz, Monika Posaric-Bauden, Karolin Isaksson, Roland Andersson, Bobby Tingstedt

  KEYWORDS: Polycations; Abdominal Adhesions; Coagulation; Fibrosis; Inflammation

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.5 No.8, July 31, 2012

  ABSTRACT: Background: Abdominal adhesions develop on damaged peritoneal surfaces and constitute a significant health related problem. Previous animal studies have shown promising anti-adhesive effects when administering the polycation α-poly-L-lysine (αPL) and the polyanion poly-L-glutamate (PG) together. The objective of the study was to examine the effect of these differently charged polypeptides when administered by spraying and to evaluate any possible effect on fibrinolysis, fibrosis and inflammation. Methods: Rabbits were treated with PLPG after cecal abrasive surgery and analysis from peritoneal biopsies of active tPa/PAI-1 complex and from peritoneal fluid of IL-6 and active TGFb1 at day 0, 1, 4 and 10 were measured after surgery. Histological specimens were analyzed on day 10 regarding inflammation and fibrosis. Peritoneal adhesions were evaluated by adhesion score. All values were compared to the control group (NaCl). Results: PLPG-treated rabbits had a significant diminished adhesion score on day 10 as compared to the control group (p